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Roman S Polishchuk Selected Research

Copper

1/2021Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content.
12/2020Pharmacoproteomics pinpoints HSP70 interaction for correction of the most frequent Wilson disease-causing mutant of ATP7B.
3/2020Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin.
6/2019Silver Ions as a Tool for Understanding Different Aspects of Copper Metabolism.
1/2019Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis.
1/2019A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats.
1/2018Characterization of the most frequent ATP7B mutation causing Wilson disease in hepatocytes from patient induced pluripotent stem cells.
1/2016Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants.
1/2016The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders.
6/2014Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis.

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Roman S Polishchuk Research Topics

Disease

9Hepatolenticular Degeneration (Wilson's Disease)
01/2021 - 06/2014
4Neoplasms (Cancer)
10/2022 - 01/2019
2Ovarian Neoplasms (Ovarian Cancer)
10/2022 - 03/2020
1Carcinoma (Carcinomatosis)
03/2020
1Fatty Liver
01/2019
1Acute Liver Failure (Fulminant Hepatic Failure)
01/2019
1Hepatocellular Carcinoma (Hepatoma)
01/2018
1Hypothyroidism
10/2017
1Menkes Kinky Hair Syndrome (Menkes Disease)
01/2016
1Inborn Genetic Diseases (Disease, Hereditary)
01/2016
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2016
1Stargardt Disease
12/2015
1Hypoxia (Hypoxemia)
12/2013
1Heart Valve Diseases (Valvular Heart Disease)
03/2013
1Dysostoses
03/2013
1Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy)
03/2013
1Vesicular Stomatitis
10/2012
1Chronic Kidney Failure (Chronic Renal Failure)
05/2010
1Hypertension (High Blood Pressure)
05/2010
1Juvenile gout
05/2010
1Hyperuricemia
05/2010
1Cystic Kidney Diseases (Cystic Kidney Disease)
05/2010
1Kidney Diseases (Kidney Disease)
05/2010
1Gout
05/2010
1Huntington Disease (Huntington's Disease)
07/2009
1Aarskog Syndrome
05/2009
1Wounds and Injuries (Trauma)
10/2007

Drug/Important Bio-Agent (IBA)

10CopperIBA
01/2021 - 06/2014
7Proteins (Proteins, Gene)FDA Link
12/2020 - 05/2009
4Copper Transport ProteinsIBA
12/2020 - 06/2014
3PlatinumIBA
10/2022 - 01/2019
2Cisplatin (Platino)FDA LinkGeneric
03/2020 - 01/2019
2MetalsIBA
01/2019 - 06/2014
2GlycosaminoglycansIBA
03/2013 - 07/2009
1Domperidone (Domperidon)IBA
12/2020
1Amphotericin B (Amphotericin)FDA LinkGeneric
03/2020
1tranilastIBA
03/2020
1Pharmaceutical PreparationsIBA
03/2020
1Telmisartan (Micardis)FDA Link
03/2020
1SilverIBA
06/2019
1Copper-Transporting ATPasesIBA
01/2019
1EnzymesIBA
01/2019
1ManganeseIBA
10/2017
1Thyroxine (Levothyroxine)FDA LinkGeneric
10/2017
1p38 Mitogen-Activated Protein KinasesIBA
01/2016
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
12/2013
1Protein Isoforms (Isoforms)IBA
12/2013
1N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)IBA
03/2013
1GTP-Binding Proteins (G-Protein)IBA
10/2012
1CollagenIBA
10/2012
1SaltsIBA
05/2010
1UromodulinIBA
05/2010
1Cadherins (E-Cadherin)IBA
10/2007
1beta CateninIBA
10/2007

Therapy/Procedure

3Drug Therapy (Chemotherapy)
10/2022 - 01/2019
1Enzyme Replacement Therapy
03/2013